Chitosan and carboxymethyl cellulose coated on NH2-UiO-66 as green, biocompatible, nontoxic, and pH-stimuli responsive for levofloxacin delivery: A comparative study
Abstract
Recently, developing an efficient and green approach to overcoming bacterial resistance in drug delivery systems has remained a significant challenge. This work is supposed to design and create two novel, green, biocompatible nanocarriers by incorporating levofloxacin-loaded NH2-UiO-66 into the chitosan and carboxymethyl cellulose biopolymers. The structural characteristics and antibacterial activity of the synthesized carriers were analyzed using FT-IR, SEM, BET, XRD, TGA-DTA, zeta potential, DLS, swelling analysis, ZOI, MIC, MBC, and MTT techniques. The in vitro release rate of the levofloxacin at acidic and neutral environments from the NH2-UiO-66/levofloxacin/carboxymethyl cellulose was 78±2.1% and 18±1.9% and from the NH2-UiO-66/levofloxacin/chitosan was 86±3.5% and 69±2.9% respectively, over 72 h. Kinetics studies showed that the Corsmeyer-Peppas and Higuchi models predicted the release mechanisms of NH2-UiO-66/levofloxacin/carboxymethyl cellulose (R2=0.97) and NH2-UiO-66/levofloxacin/chitosan nanocarriers R2=0.97, respectively. Additionally, studies of the antibacterial properties showed that two NH2-UiO-66/levofloxacin/carboxymethyl cellulose and NH2-UiO-66/levofloxacin/chitosan nanocarriers were more effective against Staphylococcus aureus bacteria than Escherichia coli bacteria. The MTT assay showed that after 48 h, the NH2-UiO-66/levofloxacin/carboxymethyl cellulose nanocarrier with a concentration of 8 mg/mL exhibited lower cell viability compared to the…
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.