2577. Comparing Omadacycline with Existing Antibiotics in the treatment of Acute Bacterial Infections: A Systematic Review
Abstract
Abstract Background Omadacycline (OMC), the first aminomethylcycline antibiotic, is a semisynthetic tetracycline derivative approved for community-acquired bacterial pneumonia (CABP) and acute bacterial soft skin infection (ABSSI), with a broad range of activity against Gram-positive and Gram-negative aerobes, anaerobes and atypical bacteria, including drug-resistant strains. It is currently under development for the treatment of cystitis and acute pyelonephritis (AP). Methods This systematic review of literature followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Abstracts were searched using the term: “omadacycline”. The electronic research literature databases included the Cochrane Library, MedLine, and clinicaltrials.gov from February to April 2023. Selection of studies by PRISMA flowchart is shown in figure 1. Characteristics of endpoints for each pathology are mentioned in table 1.Table 1. Endpoints for each disease. CABP (Community-acquired Pneumonia), ECR (Early clinical response), Investigator-assessed clinical response (IACR), Post treatment evaluation (PTE), ABSSI (Acute bacterial soft skin infection), EOT, (End of treatment), AP (Acute pyelonephritis). Results OMC was found to be noninferior to existing antibiotics in all reviewed studies. The most common side effects of OMC were nausea, vomiting and diarrhea, which were infrequent, mild and easily treatable. The only limitation of these studies was proving the…
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