An Overview of Virulence, Resistance, and Clinical Significance of Klebsiella Infections
Abstract
Gram-negative, encapsulated, non-motile bacilli called Klebsiella species are commonly found in the environment and are a natural component of both human and animal flora. Among the genus, Klebsiella pneumoniae and Klebsiella oxytoca are the most clinically significant, while emerging species such as Klebsiella variicola and Klebsiella aerogenes are increasingly recognized in human infections. These organisms act as opportunistic pathogens and are associated with a variety of community-acquired and nosocomial infections, particularly in immunocompromised and hospitalized patients. Common clinical manifestations include urinary tract infections, pneumonia, bloodstream infections, wound and soft-tissue infections, intra-abdominal infections, and meningitis. The pathogenicity of Klebsiella species is attributed to multiple virulence factors, including a prominent polysaccharide capsule, adhesins, siderophores, lipopolysaccharide, and the ability to form biofilms. In recent years, the clinical importance of these organisms has grown as a result of the global emergence of multidrug-resistant (MDR) strains. The production of extended-spectrum β-lactamases (ESBLs), AmpC β-lactamases, and carbapenemases has significantly reduced the effectiveness of commonly used antibiotics. Furthermore, MDR-hypervirulent (MDRhv) clones, which are linked to serious infections and few treatment choices, have emerged as a result of the convergence of multidrug resistance and hypervirulence. Accurate…
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.