Isolation and Epidemiology of Respiratory Bacteria From Unusual Sites: Demographic, Seasonal, and Geographic Distribution in a Laboratory-Based Study From a Tertiary Care Hospital in Karachi, Pakistan
Abstract
Introduction Respiratory pathogens such as Streptococcus pneumoniae, Haemophilus influenzae, and Haemophilus parainfluenzae primarily infect respiratory and oropharyngeal sites. However, they are increasingly being isolated from unusual anatomic sites, such as urogenital and abdominal sources. These atypical occurrences necessitate an understanding of their epidemiology and clinical implications. Methods This study aimed to evaluate the seasonal prevalence, gender distribution, and clinical characteristics of Streptococcus pneumoniae, Haemophilus influenzae, and Haemophilus parainfluenzae isolated from nonrespiratory, unusual sites. Conducted at the Clinical Microbiology Laboratory of Aga Khan University Hospital in Karachi, Pakistan, the study included data from January 2021 to July 2023. Isolates from the urogenital tract, joints, skin and soft tissue, and other invasive samples from various body sites were included, while specimens from usual sites, such as blood, cerebrospinal fluid (CSF), and respiratory samples, were excluded. Analysis was performed after excluding isolates from unknown sources and duplicate samples from the same medical record number. A descriptive analysis was conducted on a small subset of inpatients with detailed clinical histories. Results Out of 2321 samples, 464 (20.0%) were excluded, and 1857 (80.0%) were analyzed, with 49 (2.6%) isolates from unusual sites. Isolation from unusual sites was significantly associated with female gender, the years…
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.