Infection in patients with burn injury: sources, pathogens, sensitivity, and role of empirical antibiotics therapy
Abstract
BACKGROUND: Infection in the patient with burn injury is a leading cause of morbidity and mortality worldwide. Clinicians in low- and middle-income countries are often left with no option other than to commence empirical antibiotics.
OBJECTIVE: To determine the magnitude of infection in patients with burn injury, the sources of these infections, the prevalent microorganisms and their sensitivity pattern, and the sensitivity of the microorganisms to empirical therapy.
MATERIALS AND METHODS: This prospective observational study was conducted in a regional burn center in western Nigeria between October 2010 and March 2020.
RESULTS: A total of 364 patients were included in the study, with males constituting 58.5% (213) of the patients and females 41.5% (151) of the patients. The median patient age was 22 years. Flame was the most common cause of burn injury (61.5% [n = 224]). The median total body surface area burn was 22%. The majority of the patients had a clinical diagnosis of infection (85.4% [n = 311]), with the burn wound (60.8%), respiratory tract (22.2%), and urinary tract (6.1%) constituting the clinical sources of the infection. The most prevalent causes of burn wound infection were Klebsiella pneumoniae (K pneumoniae) (30.2%), Staphylococcus aureus (S aureus) (24.3%), and Pseudomonas aeruginosa (P aeruginosa) (21.0%). All cultured bacteria with the exception of Citrobacter freundii were sensitive to amikacin, with K pneumoniae and S aureus being the most sensitive to…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 364 participants or records.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.