Local multifunctional hydrogel therapy in experimental fibrinopurulent peritonitis: antibacterial, fibrinolytic, and reparative effects of a novel levofloxacin-cucumazine-NA-CMC composite
Abstract
Fibrinopurulent peritonitis (FPP) remains one of the most severe and life-threatening forms of intra-abdominal infection, with mortality rates ranging from 20% to 30% despite substantial advances in surgical source control, antimicrobial therapy, and intensive care management. The formation of extensive fibrinous deposits and bacterial biofilms within the peritoneal cavity creates a physical and biological barrier that significantly impairs the penetration and effectiveness of systemic antimicrobial agents, promotes persistent infection, enhances local inflammatory responses, and contributes to the development of postoperative adhesions and intra-abdominal abscesses. Objective: To develop and experimentally evaluate the therapeutic efficacy, biocompatibility, and reparative potential of a novel multifunctional composite hydrogel containing levofloxacin, cucumazine, and sodium carboxymethylcellulose (LCSC) for local treatment of fibrinopurulent peritonitis. Materials and Methods: The efficacy study was performed on 84 adult white rats with experimentally induced fibrinopurulent peritonitis using a modified distal cecal ligation and puncture (DCLP) model that closely reproduces the clinical and morphological features of diffuse peritonitis in humans. Animals were randomly assigned to three groups: control (saline lavage), levofloxacin (0.1% levofloxacin solution), and experimental (local application of LCSC hydrogel). Clinical, microbiological, histological, and morphometric…
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Evidence Hub reads this as a randomized trial. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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