Osteoradionecrosis Incidence and Dental Implant Survival in Irradiated Head and Neck Cancer Patients: A Systematic Review and Meta-Analysis
Abstract
BACKGROUND AND AIM
The use of implants in irradiated patients has been critically questioned due to the presence of Osteoradionecrosis and other side effects of radiation therapy. Hence, our objective is to examine the likelihood of dental implant survival and the incidence of osteoradionecrosis in patients with head and neck cancer who have undergone radiation therapy. This analysis will aid in making informed therapeutic decisions on oral rehabilitation for individuals at high risk, ensuring maximal benefit.
METHOD
PubMed, Scopus, and Web of Science were queried until April 2024. The digital data were extracted using the Web plot digitizer. We utilized the most recent iteration of STATA (version 18) to perform a meta-analysis of the data. The studies were evaluated for quality using the New Castle-Ottawa Scale. Egger's test was used to evaluate the presence of publication bias caused by modest research effects.
RESULT
The study analyzed data from 21 research papers on 753 head and neck cancer patients. The majority were male, with a mean age of 60.25 years. 46% underwent radiotherapy, with 2261 dental implants inserted. The mandible was the most used implant site, accounting for 62.4%. The mean time between implant placement and radiotherapy was 5.3 weeks, with a median waiting period of 30.7 months for secondary surgery. After an average follow-up of 42.25 months, 58% of implants failed in the irradiated control group, while 6% failed in the non-irradiated control…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 26 participants or records.
Read the paper
Related studies
- Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials
- Tocilizumab in patients with severe COVID-19: a retrospective cohort study
- A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study
- Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study
- Are noise and air pollution related to the incidence of dementia? A cohort study in London, England
- Long COVID symptoms and duration in SARS-CoV-2 positive children — a nationwide cohort study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.