The effect of fumaric acid on ruminant enteric methane emission and ruminal volatile fatty acids concentration: a meta-analysis
Abstract
Abstract Methane emitted by ruminants represents an energy loss from feed intake and contributes to global warming. Fumaric acid (FA), a key intermediate in rumen metabolism, acts as an alternative electron acceptor and offers a potential strategy to reduce methane production. This meta-analysis systematically evaluated the effects of FA supplementation on enteric methane emissions and rumen fermentation in ruminants. Thirteen peer-reviewed studies met the inclusion criteria, contributing 22 effect sizes from 13 studies: six on cattle (dairy and beef cattle), seven on small ruminants (sheep and goats). Effect sizes were calculated as mean difference (MD) for methane yield (g/kg dry matter intake [DMI]), relative mean difference (RMD) for methane production (g/day) and DMI (kg/day), and standardized mean difference (SMD) for volatile fatty acids. A multilevel meta-analysis model was used to account for study-level variation. FA supplementation had no effect on DMI (P = 0.25; RMD = –2.75) but significantly reduced methane production (P = 0.005; RMD = –19.21). Meta-regression showed that increase in FA (g/kg DMI) decreases in methane production by 0.272% (P = 0.02). Methane production was significant in small ruminants (P = 0.002; RMD = –24.67) but not in cattle (P = 0.52; RMD = –7.03). The effectiveness of FA in reducing methane production was not (P > 0.05) affected by variations in dietary forage, concentrate, or neutral detergent fiber (NDF) content in FA-supplemented…
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Evidence Hub reads this as a meta-analysis, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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