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Association between glucagon‐like peptide‐1 receptor agonist use and peri‐operative pulmonary aspiration: a systematic review and meta‐analysis

J. Elkin, S. Rele, P. Sumithran, M. Hii, S. Thuraisingam, T. Spelman, T. Phan, P. Choong et al.

Anaesthesia, 2025

59 citations

Abstract

Glucagon‐like peptide‐1 receptor agonists are known to delay gastric emptying; however, the association between glucagon‐like peptide‐1 receptor agonist use and peri‐operative pulmonary aspiration risk is not known. This systematic review and meta‐analysis aimed to summarise the evidence on whether glucagon‐like peptide‐1 receptor agonist exposure is associated with pulmonary aspiration or increased residual gastric content in fasted patients undergoing procedures requiring anaesthesia or sedation.

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Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.

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