Effects of aerobic or resistance exercise during neoadjuvant chemotherapy on tumor response and therapy completion in women with breast cancer: The randomized controlled BENEFIT trial
Abstract
Highlights • In 180 women with breast cancer undergoing neoadjuvant chemotherapy, effects of supervised aerobic or resistance exercise on tumor and chemotherapy outcomes were modified by hormone receptor (HR) status.• Among patients with HR+ tumors, the exercise interventions showed beneficial effects on change in tumor size, pathologic complete response, and axillary lymph node dissection compared to a waitlist control group.• Among patients with HR– tumors, exercise was significantly associated with higher relative dose intensity compared to controls.• The rate of premature discontinuation of chemotherapy was significantly lower among patients receiving an exercise intervention compared to controls, irrespective of HR status.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 180 participants or records.
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