Non‐Surgical Treatment of Moderate Periodontal Intrabony Defects With Adjunctive Cross‐Linked Hyaluronic Acid: A Single‐Blinded Randomized Controlled Clinical Trial
Abstract
ABSTRACT Aim To evaluate the clinical outcomes of moderate intrabony defects treated with minimally invasive non‐surgical technique (MINST) with or without adjunctive delivery of cross‐linked hyaluronic acid (xHyA) gel. Materials and Methods Forty‐two patients with 42 interdental intrabony defects were randomly assigned to test (MINST + xHyA) or control procedures (MINST alone). Probing depth (PD), clinical attachment level (CAL), gingival recession (GR) and bleeding on probing (BOP) at the treated sites were assessed at baseline and at 3 and 6 months. Full‐mouth plaque score (FMPS) and full‐mouth bleeding score (FMBS) were recorded at baseline and after 6 months. Radiographic evaluation was performed at baseline and after 6 months, assessing the defect fill (DF) and radiographic defect angle (RDA). The primary outcome variable was PD change. Results Thirty‐eight patients completed the trial without any adverse events. At 6 months, a statistically significant improvement (p 0.05). However, no statistically significant differences were found between the experimental and control procedures (p > 0.05). Statistically significant differences between the test and control sites were observed at 3 months for PD and CAL changes (p 0.05). Conclusion Within their limitations, the present results indicate that (a) treatment of intrabony defects with MINST, with or without application of xHyA gel, resulted in statistically significant improvements in the investigated clinical parameters…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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