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Association between the changes in the estimated glucose disposal rate and new‐onset cardiovascular disease in middle‐aged and elderly individuals: A nationwide prospective cohort study in China

Lu Yan, Zhe Zhou, Xing Wu, Yumin Qiu, Zhe-Fu Liu, Li Luo, Yang Yang, Xi Lu et al.

Diabetes, obesity and metabolism, 2025

25 citations

Abstract

Previous studies have shown that eGDR and TyG, as indicators of insulin resistance (IR), were key risk factors for cardiovascular disease (CVD). Our study further explored the relationship between eGDR change and new‐onset CVD, and compared the predictive value of eGDR change, eGDR and TyG.

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Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.

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