Clinical risk factors associated with nosocomial Pseudomonas aeruginosa bacteraemia in patients within a tertiary care healthcare setting – a case control study
Abstract
P. aeruginosa is a major cause of hospital-acquired infections, particularly in healthcare settings in the UK and Europe. In 2017, the number of patients with P. aeruginosa bacteraemia in a London teaching hospital was increasing and demographic studies had attempted to identify the cause. A case–control study was undertaken with the aim to determine the pre-existing risk factors for developing P. aeruginosa bacteraemia among hospital inpatients, many of whom were immunocompromised. Multivariable, matched, case-control analysis using conditional logistic regression was performed to determine the risk factors associated with acquisition of P. aeruginosa bacteraemia at a tertiary care teaching hospital (800 patient beds; 98 beds for haematology patients) in London, UK. The cases were 137 patients with hospital-onset P. aeruginosa detected in blood and two control groups comprising a total of 845 patients (treated between April 2015 – July 2018). The analysis included the following predictor variables: admission method, blood test results, known viral infection, presence of central lines, surgical history, urinary tract infection and P. aeruginosa detected in urine, wound, or respiratory system. SPSS and R were used for the statistical analysis. Of 135 patients with bacteraemia due to Pseudomonas aeruginosa, 23 (17%) died within 30 days compared with 20 (4.1%) of 488 matched patients with no bacteraemia and 24 (6.7%) of 357 patients with other causes of bacteraemia. Analysis…
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 845 participants or records.
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