Assessment of the Impact of Obesity on Coagulation Profile and D-Dimer Levels among Obese Adults in Shendi Locality, Sudan: A Case-Control Study
Abstract
Background: Obesity is a major global health concern and an established independent risk factor for venous thromboembolism (VTE). Excess adipose tissue promotes chronic low-grade inflammation, endothelial dysfunction, increased coagulation activity, and impaired fibrinolysis, resulting in a hypercoagulable state. This study aimed to evaluate the effect of obesity on routine coagulation parameters and D-dimer levels among obese individuals in Shendi Locality, Sudan.
Methods: A case-control study was conducted in Shendi Locality, River Nile State, Sudan, between September and December 2025. The study included 100 participants, comprising 70 obese individuals (case group) and 30 apparently healthy individuals (control group). Venous blood samples were collected to determine prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), and D-dimer levels. Demographic characteristics, including age, sex, body mass index (BMI) classification, and family history of obesity, were recorded. Statistical analyses were performed using the independent samples t-test and one-way ANOVA, with statistical significance set at p < 0.05. Results: Obese participants demonstrated significantly shorter PT (11.08 ± 1.87 vs. 13.54 ± 1.37 seconds, p < 0.001), lower INR (0.78 ± 0.14 vs. 0.96 ± 0.10, p < 0.001), and shorter APTT (15.85 ± 7.16 vs. 28.78 ± 5.53 seconds, p < 0.001) compared with the control group. In addition, D-dimer levels were significantly…
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 100 participants or records.
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