Analysis of the efficacy of fosfomycin trometamol in preventing biofilm bacterial infection in double-J stents among diabetic patients and the factors associated with infection
Abstract
OBJECTIVE: To evaluate the efficacy of fosfomycin trometamol powder (FMT) in preventing biofilm-associated bacterial infections on double-J stents in diabetic patients; to characterize the species distribution and antimicrobial susceptibility patterns of biofilm-forming bacteria isolated from these devices; and to identify clinical and microbiological risk factors associated with such infections-thereby informing evidence-based strategies for infection prevention in this high-risk population.
METHODS: A total of 100 adult diabetic patients who underwent double-J stent placement at our tertiary care center between June 2024 and June 2025 were prospectively enrolled and randomized in a 1:1 ratio to either an experimental group or a control group (n = 50 per group). Patients in the experimental group received a single oral dose of 3 g FMT on the day before stent insertion and on postoperative days 7 and 15; those in the control group received a single oral dose of 0.5 g levofloxacin (LFX) tablets on the day before stent insertion and on postoperative days 1 and 2. At the time of stent removal, stent surface specimens were collected for quantitative biofilm-forming bacterial culture, species identification, and antimicrobial susceptibility testing. Baseline clinical characteristics, stent-related symptoms, and infection outcomes were systematically recorded. Statistical analysis was conducted using SPSS version 26.0, with two-sided p < 0.05 considered statistically significant.…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 100 participants or records.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.