Association between metabolic score for insulin resistance (METS-IR) and hypertension: a cross-sectional study based on NHANES 2007–2018
Abstract
Insulin resistance (IR) reduces insulin efficacy and heightens the danger of cardiovascular diseases including hypertension. The Metabolic Score for Insulin Resistance (METS-IR), which is based on triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), body mass index (BMI), and fasting glucose levels, provides a simpler way to assess IR. As the hypertension’s prevalence increases, particularly in those with metabolic disorders, exploring the relationship between hypertension and METS-IR has become crucial. 16,310 individuals from the 2007–2018 National Health and Nutrition Examination Survey dataset was included. Hypertension was defined by asking participants about their medical history and blood pressure measurements. METS-IR was calculated as follows: ln([ HDL-C (mg/dL)] × [2 × fasting glucose (mg/dL)] + TG (mg/dL) × BMI (kg/m2)). The study adjusted for covariates like sex; age; race; poverty-income ratio; marital status; educational background; total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and serum creatinine levels; smoking; stroke; alcohol consumption; diabetes; and coronary heart disease (CHD). This study was conducted using a multi-factor regression model. This research demonstrated a significant positive relationship between hypertension and METS-IR. Each 1-unit rise in METS-IR corresponds to a 3% higher chance of hypertension (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.03–1.04). In model 3, METS-IR exhibited a…
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