Associations of NPAR index with breast cancer incidence and mortality based on the National Health and Nutrition Examination Survey (NHANES) 2001-2018: a cross-sectional study
Abstract
BACKGROUND
Breast cancer (BC) remains one of the most prevalent cancers affecting women globally, imposing significant health and economic burdens on both patients and society. This study aims to investigate the relationship between the neutrophil percentage to albumin ratio (NPAR) and BC risk and mortality.
MATERIALS AND METHODS
Clinical data from 13,540 participants in the NHANES database were analyzed, including 331 individuals with a documented history of BC. Survival analysis and advanced machine learning (ML) techniques were applied to assess the data.
RESULTS
Higher NPAR levels were significantly associated with increased BC risk in the unadjusted model, with quartile comparisons revealing an odds ratio (OR) of 1.51 (95% CI: 0.99-2.29, p = 0.057). After adjustment, the OR increased to 1.70 (95% CI: 1.12-2.57, p < 0.05), indicating the robustness of this association. Elevated NPAR levels were also linked to higher all-cause mortality (ACM). Multivariate Cox regression models showed that a one-unit increase in NPAR was associated with adjusted hazard ratios of 1.09 (95% CI: 1.07-1.12) for overall mortality and 1.17 (95% CI: 1.13-1.22) for cardiovascular disease mortality, both with p-values < 0.001. Restricted cubic splines analysis revealed a linear correlation between NPAR and BC risk (p for nonlinearity = 0.15), while a nonlinear relationship was observed for ACM (p for nonlinearity < 0.01). Among nine ML models evaluated, the LightGBM model exhibited the best…
Read the paper
Related studies
- Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials
- Tocilizumab in patients with severe COVID-19: a retrospective cohort study
- A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study
- Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study
- Are noise and air pollution related to the incidence of dementia? A cohort study in London, England
- Long COVID symptoms and duration in SARS-CoV-2 positive children — a nationwide cohort study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.