Reported Early Clinical Outcomes of Forward-Planned Multileaf Collimator-Based 3-Dimensional Conformal Spatially Fractionated Radiation Therapy Technique for Large and Bulky Tumors
Abstract
PURPOSE
Conventionally fractionated radiation therapy for large, bulky (≥8 cm), unresectable tumors has been hampered by radiation-induced morbidity, but application of spatially fractionated radiation therapy (SFRT) for both palliative and curative intent has been increasingly accepted. We report our clinical use of novel 3-dimensional conformal multileaf collimator (MLC)-based SFRT with same-day computed tomography simulation and forward-planning method, providing a safe, rapidly efficacious reduction in disease burden and pain, with minimal normal-tissue toxicity.
METHODS AND MATERIALS
Patients with large, unresectable bulky tumors received 15 Gy in 1 fraction to the gross tumor volume (GTV) within an hour of computed tomography simulation, using a forward-planned MLC-based SFRT technique. All patients subsequently received either 30 Gy in 10 fractions, generally 2 days after SFRT for palliative intent, or site-specific, full-prescription doses starting 2 to 3 days after SFRT for curative intent. Patients underwent follow-up examinations and imaging in 3-month intervals to assess tumor response, pain control, and radiation-associated toxicity.
RESULTS
Between November 2019 and January 2024, 24 large tumors in 23 patients were analyzed. Median follow-up was 6 months (range 3-36 months). After SFRT, 16 patients (69.5%) proceeded with palliative-intent radiation therapy, 6 patients (26.0%) underwent curative-intent radiation therapy, and 1 patient (4.3%) declined further…
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