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Abstract PS1-07-30: Cherenkov Imaging as a Real-Time Quality Improvement Tool in Breast Radiotherapy: A Case Series

A. Matous, E. Chen, L. Jarvis

Clinical Cancer Research, 2026

Abstract

Radiotherapy is an essential component of definitive treatment for many patients with breast cancer. Cherenkov imaging is an emerging optical imaging technology that enables visualization of radiotherapy beams on the patient’s surface in real-time. The anatomy and treatment setup of breast radiotherapy make it particularly well suited for evaluation with this technique. While Cherenkov imaging typically confirms accurate treatment delivery, it has also revealed instances of irradiation to unintended tissues. We hypothesized that Cherenkov imaging could be used as a quality improvement tool to identify and minimize radiation dose to normal tissues among patients receiving radiotherapy for breast cancer.

As part of a prospective clinical trial, Cherenkov images were reviewed daily for all patients receiving breast radiotherapy at 1 academic and 1 community medical center. When dose to anatomical regions outside the treated breast was identified on Cherenkov images, a root cause analysis was performed to determine contributing factors. Treatment plans were re-evaluated using the treatment planning system (TPS), and modifications were made when clinically appropriate.

•Case 1: Cherenkov imaging identified unexpected dose on the ipsilateral back of a patient treated in the prone position. TPS review revealed an anterior-posterior (AP) beam exiting through the heart. The plan was revised to eliminate the AP field, and institutional practice was updated to minimize heart and lung…

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