Investigations into hyperspectral and hybrid-optical imaging for bio-applications
Abstract
A pushbroom hyperspectral imaging probe based on spatial-scanning method was conceptualised and developed for the first time.The imaging probe is an assembly of a gradient index lens and an imaging fiber optic bundle.The lateral resolutions along the horizontal and vertical directions at 505 nm are about 40 μm.The scope of existing tabletop pushbroom hyperspectral imager was extended by enabling it to perform endoscopic bio-imaging using a flexible imaging probe.The pushbroom hyperspectral imaging probe can be used to image the colon for the detection of cancer progression of different stages, while it is generally difficult to access using the conventional table-top systems.A snapshot hyperspectral video-endoscope is developed using a custom-fabricated twodimensional to one-dimensional fiber bundle.It converts a pushbroom hyperspectral imager into a snapshot configuration.The fiber bundle is flexible and has a small distal end, enabling it to be used as an imaging probe.It can be inserted into the colon for minimally invasive and in vivo investigations for the detection of cancer.The three-dimensional datacubes can provide vast amount of information, which includes the spatial features (shape and size), spectral signatures, speed and direction of the imaged samples.A hyperspectral photoacoustic spectroscopy system to acquire the normalised optical absorption coefficient spectrum of highly-absorbing bio-samples is also proposed and developed.This allows the characterisation…
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