Patient-specific tracer activity in MPI SPECT: A hands-on approach
Abstract
Previously, several studies have reported that a decreasing image quality in heavier patients in myocardial perfusion imaging (MPI) using single-photon emission computed tomography (SPECT) can be compensated by using a body-weight-dependent tracer activity or scan time,1-3 as illustrated in Figure 1. Although we derived and validated a activity-scan-time formula for a conventional SPECT scanner, this formula cannot simply be used for all SPECT scanners.1 Differences in detector sensitivity, technical specifications such a collimator design and geometrical detector configuration, and acquisition and reconstruction settings limit the generalizability of the derived formula. Ideally, a tracer activity-scan-time formula should therefore be derived for each SPECT scanner using the method as described previously.1 However, this could be technically challenging and is time consuming. In this technical note, we therefore introduce, as a first-order approach, an alternative simplified method to obtain a body-weight-dependent protocol, which can easily be adopted in every day patient care.
Figuer 1
Example of constant image quality in MPI SPECT scans of three male patients without any perfusion defects with varying body weights. From left to right: 66 kg (22.6 kg·m−2), 85 kg (25.1 kg·m−2 ...
Deriving a Body-Weight-Dependent Protocol
In cardiac SPECT, the application of a fixed tracer activity and scan-time protocol results in a decreasing number of photon counts in heavier patients…
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