Synthesis, Characterization, In vitro and In silico Studies of a Novel Hydrazone Compound
Abstract
The geometric increase of drug-resistant bacteria pathogens has made urgent the research, development and production of new antibacterial and antifungal compounds, hence the synthesis of this novel compound as a potential antibacterial drug. As hydrazones enhanced generally with thiazoles which are 5-membered ring compound containing active nitrogen and sulphur molecules (C3H3NS) have been proven to exhibit strong antibacterial and antifungal activities, in this study, salicylaldehyde -4- thiazoleacetic acid hydrazone(SAFTAH) compound was synthesized. The novel compound was characterized and subjected to anti-microbial screening. The microbes employed were staphylococcus aureus, Escherichia Coli, streptococcus and klebsialla aerogene. The compound was found to be active against Escherichia coli as the test result recorded ++ indicating ‘very active’ unlike the other three microbes which either had + or none. To validate this inhibition of Escherichia coli by the novel compound and to detect the active site of their interactions, in silico molecular docking analysis of the novel compound against aminopeptidase N from E. coli which is known to promote virulence to the microbe in question was carried out. Six drugs commonly used for the treatment of E. coli vis-a-viz, ciprofloxacin, levofloxacin, doxycycline, rifamycin, rifaximin and sulfamethoxazole were subjected to same type of silico studies. The result of the docking indicated that the novel hydrazone compound is more…
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Evidence Hub reads this as a simulation / modelling, done in cell cultures (in vitro) and computer models (in silico), not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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