First-in-human H-scan ultrasound imaging of breast cancer
Abstract
H-scan ultrasound (US) is a new imaging technique based on a simplified framework for characterizing the relative size of acoustic scatterers and visualizing the results as color-coding of the matched B-scan US image. Several reports in the literature have demonstrated the utility of H-scan US for visualizing breast cancer and monitoring response to drug treatment in preclinical animal models. The purpose of this research was to explore H-scan US imaging of human breast cancer and present first-in-human results. As part of a multisite clinical trial at Thomas Jefferson University and University of Texas Southwestern Medical Center, patients newly diagnosed with locally advanced breast cancer and scheduled to receive neoadjuvant chemotherapy (NAC) were enrolled in this study. Imaging was performed using a clinical US scanner (Logiq E9, GE Healthcare) equipped with an 9L-D linear array transducer that was modified as an investigational device. Beamformed radiofrequency (RF) data was acquired at 9 MHz in both the transverse and longitudinal planes and saved for offline analysis. Two digital filters were constructed using 2nd and 8th order Gaussian-weighted Hermite polynomial functions and convolved in parallel with each RF data sequence to measure the relative strength of the backscattered US signals. The signal envelope for each filter output was then calculated and color coded to form the final H-scan US image. All tumor locations and boundaries were identified by a trained…
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