Performance Comparison of a Vibrating Mesh Nebulizer and Air Entrainment Jet Nebulizer in an Adult, Pediatric and Infant Spontaneously Breathing Model
Abstract
Background: The air entrainment jet nebulizer (AEJN) is a type of jet nebulizer designed to deliver similar aerosol dose in less time and are marketed as a faster delivery device. Although time to deliver a dose may be a consideration in the selection of a device, more important factors include; delivered lung dose and patient clinical response. In vitro bench, imaging and clinical studies comparing jet nebulizer to vibrating mesh nebulizer (VMN) consistently demonstrate superior performance of VMN. We hypothesized that VMN would provide greater % tracheal dose compared to AEJN. Methods: Mask-mediated aerosol delivery with VMN (Aerogen Solo with Ultra, Aerogen Ltd., Galway, Ireland) and AEJN (Airlife Misty Fast, Carefusion Inc., Yorba Linda, CA) were compared in adult and pediatric models connected to a sinusoidal pump via a collecting filter at the level of the trachea. The following settings were used to simulate a spontaneously breathing adult (VT 500 mL, 15 breaths/min, I:E ratio 1:1) and pediatric model (VT 300 mL, 20 breaths/min, I:E ratio 1:2. The infant model utilized a blow-by interface held ½ inch from the upper airway of the spontaneously breathing lung model (VT 50 mL, 30 breaths/min, I:E 1:3). The VMN was powered by the Pro-X controller with a driving gas flow of 2L/min from a 30 psi source (Aerogen, Galway, Ireland) and the AEJN powered by 8 L/min gas flow from a 30 psi source. The AEJN was loaded with a (2.5 mg/3 mL) solution of albuterol and aerosolized to…
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