Quantitative ultrasound in obstetrics and perinatal care
Abstract
This talk will present recent results from our multi-institutional effort to advance the application of Quantitative Ultrasound in obstetrics and in perinatal care. In the field of obstetrics, we are investigating the use of shear wave elasticity imaging (SWEI) to predict the risk of preterm birth based on assessing the viscoelastic properties of the uterine cervix. Longitudinal studies in non-human primates (NHP) and humans showed a similar rate of decrease of the shear wave speed, SWS (1.6% and 1.5%/% gestational age, respectively), validating the animal model and indicating the value of SWS change as a biomarker for cervical softening. We are currently optimizing the analysis of shear wave dispersion to assess changes in viscosity. In the field of perinatal care, results from a pilot study in NHP neonates suggest that the effective size of diffuse scatterers can be used as a biomarker for thalamic apoptosis induced by long exposures to anesthesia. We are currently investigating the use of coherent scattering features to increase the sensitivity and specificity to neuroapoptosis and to improve attenuation and backscatter coefficient estimations in complex tissues such as the cervix and the neonate brain. [Acknowledgments: All protocols have been IRB- and/or IACUC-approved, and are HIPAA compliant. Equipment loan and technical support from Siemens Healthcare. Funded by: NIH Grant Nos. T32CA009206, F31HD082911, R01HD072077, UL1TR000427, P51OD011106, and R01HD083001; NSERC…
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