The Cytogenetic Effects of Levofloxacin in Male Rats
Abstract
T he main active substances of quinolones and fluroquin- lones are cinoxacin, ciprofloxacin, enoxacin, flumequin levofloxacin, lomefloxacin, moxifloxacin, nalidixic acid, norfloxacin, ofloxacin, pefloxacin, pipemidic acid, prulifloxacin, and rufloxacin.broad spectrum antibiotics, which are widely prescribed and are important for treating serious, life threatening bacterial infections (European Medicine Agency, 2018; Blessed et al., 2018).Fluroquinolones are now being used for treatment of various bacterial diseases in animals.An emergence of bacterial resistance against this class of drugs needs great efforts to evaluate the newer fluroquinolones for therapy in human and veterinary medicine (Patel et al., 2012a).Levofloxacin is a third-generation fluoroquinolone that possesses activity against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate ac-tivity against anaerobes, as well as atypical pathogens such as Mycoplasma and Chlamydia (Aboubakr and Soliman, 2014).The inhibition of DNA gyrase, (enzyme required for DNA replication, transcription, repair and recombination) is the specific mechanism of action of levofloxacin and other fluoroquinolones antibacterials (Bano et al., 2014).Levofloxacin is well distributed toward target body tissues, so it uses in treatment of urinary tract infection (complicated and uncomplicated) and community-acquired pneumonia, including multidrug resistant strains of several bacteria (Levaquin, 2018).In veterinary…
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