Investigation into swept source based optical coherence tomography for bio-imaging
Abstract
Optical imaging at both the macroscopic and microscopic levels is used intensively these days by clinicians for diagnosis and treatment. New advances in optics, data acquisition, and signal processing enabled the development of novel optical imaging technologies with enhanced imaging capabilities for targeted applications. Further, optical imaging technologies are more affordable than conventional radiation based technologies and provide both structural and functional information with enhanced resolution. Among different optical imaging modalities, optical coherence tomography (OCT) has gained a special attraction since it allows a non-invasive and in-vivo subsurface imaging of the biological specimen at high resolution and relatively better penetration depth. Fourier-domain OCT (FDOCT) configurations are highly attractive for many diagnostic imaging applications due to their potential for high speed imaging with high sensitivity. Nevertheless, the imaging capability and applicability of OCT are often challenged by the factors such as complex and delicate system design, degradation of axial resolution and sensitivity, and reduced contrast. Accordingly, intense efforts aimed at making technical improvements in resolution, image quality, and functional capabilities are underway among the scientific community. A compact FDOCT system based on swept-source configuration (SSOCT) with enhanced imaging capabilities has been proposed and demonstrated in this thesis. An interferometry…
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