Development of an In Vivo Bone Tungsten K‐X‐Ray Fluorescence Detection System
Abstract
ABSTRACT The versatility of tungsten (W) in electronics as well as in industrial and military applications has established it as one of the metals more present in our daily lives. Recent studies have highlighted its potential in the healthcare sector, including using sodium tungstate for anti‐diabetic treatment and W nanoparticles to enhance radiation therapy. With these expanding applications, W exposure to the public is increasing, necessitating the potential monitoring and investigation of W concentrations in humans. Tungsten exposure may lead to adverse health effects, such as pulmonary dysfunction, immune disorders, and cancer. In this study, we propose a design of an in vivo bone W K‐X‐ray Fluorescence diagnostic tool utilizing Monte Carlo modeling. Various excitation sources and detection geometries were explored to optimize the minimum detection limit and propose an effective diagnostic tool design. The modeling revealed that Cd or Co arranged in a 180° geometry exhibited a suitable detection limit and radiation dose for bone W quantification. However, the Cd excitation source arranged in a 180° geometry between the detector and bone is selected. Moreover, we investigated the normalization of W bone signals to enhance the clinical robustness of the diagnostic tool. Different normalization techniques were considered, including coherent, total spectrum, and Compton normalizations. It was demonstrated that Compton normalization outperformed coherent and total spectrum…
Read the paper
Related studies
- Characterization and Analysis of Porosity and Pore Structures
- Practical considerations for conducting ecotoxicity test methods with manufactured nanomaterials: what have we learnt so far?
- Dental Optical Coherence Tomography
- Radiation-shielding concrete: A review of materials, performance, and the impact of radiation on concrete properties
- Testing entanglement of annihilation photons
- Calanus finmarchicus seasonal cycle and diapause in relation to gene expression, physiology, and endogenous clocks
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.