SmART: dosimetry and applications
Abstract
Recently, 3-D CRT is being replaced with intensity-modulated radiotherapy (IMRT) and volumetric modulated radiotherapy (VMAT), which allows an even greater control over the shape of the dose distribution using multi-leaf collimators (MLC) 13 .The possibilities to which field shapes can conform to the target make the decisions by experience radiotherapy technicians to define these field shapes intractable.Consequently, inverse planning is required whereby mathematical optimization algorithms such as simulated annealing propose optimum treatment plans that achieve specific treatment goals desired by the radiation oncologist.It suffices to say that the technical capability ORGANIZATION OF THIS THESISIn this Chapter 1, a general introduction is given on the background and importance of radiation therapy and of preclinical radiation research.In particular, an emphasis is placed on being able to replicate, as best as possible, clinical radiation therapy practices in small animal studies such that the resulting research can be translational; this is made possible by new commercially available small animal image-guided precision irradiators.Chapter 2 is a thorough review of the efforts of others to performal conformal irradiation studies using the commercially available devices or bespoke ones created in-house.Advice is given on the desired requirements that these devices should possess in order to best replicate the equivalent clinical counterpart.Lastly, in this chapter a…
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