Study on the effect of coagulation tissue refinement of medical biodegradable magnesium alloys on in vivo degradation and intraosseous growth of rat femurs during long-term fixation
Abstract
Magnesium alloys as metal matrix biomaterials have attracted the attention of scholars.In vivo and in vivo, magnesium alloys have biocompatibility, a biodegradation process that does not produce toxic metal ions, degradation products that can be absorbed by the human body, they do not illicit a systemic inflammatory response, and they do not affect blood cells.In vivo cytological experiments have shown that magnesium alloys do not inhibit the growth and differentiation of mouse bone marrow cells, and they enhance the adhesion function of osteoblasts.The above characteristics of magnesium and its alloy make it a promising new absorbable internal fixation material with sufficient mechanical strength, non-toxicity, and no immunogenicity in vivo.Previous studies have shown that the use of the vertical twin-roll casting (VTRC) method can greatly optimize the properties of magnesium alloys, especially regarding corrosion resistance.This study investigated the influence of casting parameters on the properties of magnesium alloys.Mg-Re alloys were prepared at different speeds such as 10 m/min, 16 m/min, 24 m/min, and 30 m/min and analyzed by electron backscattering diffraction (EBSD).The microstructure, corrosion behavior, and bone reaction in vivo were investigated in detail.The results show that the corrosion resistance of the alloy increases with an increase in the casting speed and finer grain size of the cast-rolled parts.Among the four castings, VTRC-30m/min castings had the…
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