Brillouin imaging for studies of micromechanics in biology and\n biomedicine: from current state-of-the-art to future clinical translation
Abstract
Brillouin imaging is increasingly recognized to be a powerful technique that\nenables non-invasive measurement of the mechanical properties of cells and\ntissues on a microscopic scale. This provides an unprecedented tool for\ninvestigating cell mechanobiology, cell-matrix interactions, tissue\nbiomechanics in healthy and disease conditions and other fundamental biological\nquestions. Recent advances in optical hardware have particularly accelerated\nthe development of the technique, with increasingly finer spectral resolution\nand more powerful system capabilities. We envision that further developments\nwill enable translation of Brillouin imaging to assess clinical specimens and\nsamples for disease screening and monitoring. The purpose of this review is to\nsummarize the state-of-the-art in Brillouin microscopy and imaging with a\nspecific focus on biological tissue and cell measurements. Key system and\noperational requirements will be discussed to facilitate wider application of\nBrillouin imaging along with current challenges for translation of the\ntechnology for clinical and medical applications.\n
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