Prevalence and Antimicrobial Susceptibility Profile of Stenotrophomonas maltophilia in a Tertiary Care Hospital in Eastern India: A Five-Year Trend Analysis
Abstract
Background and objectives: Stenotrophomonas maltophilia (S. maltophilia) is an emerging pathogen causing hospital-acquired infections, particularly in critically ill and immunocompromised patients. Limited therapeutic options are available due to its multidrug resistance (MDR) nature. Despite the availability of advanced automated diagnostic methods in Eastern India, data describing its prevalence and antibiotic susceptibility patterns are limited. The present study was conducted to evaluate the prevalence, antimicrobial susceptibility patterns, and resistance trends of S. maltophilia over five years in a tertiary care hospital in Eastern India. Materials and methods: A retrospective laboratory-based observational study was conducted in the Department of Microbiology at Kalinga Institute of Medical Sciences (KIMS), a tertiary care hospital in Eastern India. Records of patients with positive culture reports for S. maltophilia isolates between January 2021 and December 2025 were analyzed after Institutional Ethics Committee approval (KIIT/KIMS/IEC/2616/2026). Clinically significant S. maltophilia isolates from various clinical specimens of hospitalized patients aged >18 years were included in the study. Samples were processed using standard microbiological procedures. Isolate identification was performed by VITEK 2 compact automated system (bioMérieux, Marcy-l'Étoile, France) and/or MALDI-TOF MS (VITEK MS PRIME system -bioMérieux, Marcy-l'Étoile, France). Antimicrobial…
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