Efficacy and safety of high dosage levofloxacin injection in the treatment of hospital-acquired pneumonia in intensive care unit
Abstract
Objective To evaluate the clinical efficacy and safety of high dosage levofloxacin injection in the treatment of hospital-acquired pneumonia(HAP) in intensive care unit (ICU). Methods Eighty-four patients with HAP in ICU from September ,2007 to December, 2008 were randomly divided into high dosage (HD group, n = 50 ) and routine dosage levofloxacin injection treated group (control group, n = 34), HD and control group both received intravenous drip of levofloxacin 500mg, once per 16 hours and once per 24 hours respectively, therapeutic efficacy and adverse reactions in both groups were observed. Results The total efficacy rate of HD and control group was 88. 00% and 76. 47% respectively, there was no significant difference between the two (x~2 = 1. 94, P0. 05); The effective time were (4. 18±2. 62)d and (5. 64±2. 72)d, the course of treatment were (7. 87±3. 66)d and (9. 64±3. 52)d, bacterial eradication rate was 86. 00% and 64. 71 % , respectively, there were significant difference between two groups (t = 2. 47, P0. 01; t = 2.19, P0. 05;x~2=4.10, P0. 05); adverse reactions were observed in 12. 00% and 8. 82% of patients in two groups respectively, there was no statistical significance (x~2 = 0. 01, P0. 05). Conclusion High dosage levofloxacin is effective and safe for HAP in patients in ICU, and can save time for saving life, maybe widespread used.
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