Efficacy and safety of modified Xuanbai Chengqi Decoction as an adjunctive treatment for severe pneumonia: a systematic review and meta-analysis
Abstract
Objective To evaluate the efficacy and safety of Modified Xuanbai Chengqi Decoction as an adjunctive therapy for severe pneumonia (SP) and to explore its clinical rationale. Methods A comprehensive search was performed in CNKI, Wanfang, VIP, CBM, Cochrane Library, PubMed, and Embase, covering database inception to November 2024. Randomized controlled trials that investigated the combination of Modified Xuanbai Chengqi Decoction with standard therapy for severe pneumonia were included. Quality evaluation, meta-analysis, and bias assessments were performed with Review Manager 5.4, using risk ratios and mean differences (MD), both with 95% confidence intervals to estimate effects. Results A total of 14 RCTs involving 1,061 participants met the inclusion criteria. Meta-analysis indicated that adjunctive treatment with the decoction achieved better overall response rates [RR = 1.21, 95% CI (1.14, 1.28), P < 0.00001] and demonstrated significant reductions in interleukin-6 (IL-6, MD = −15.07, 95% CI (−17.31, −12.83), P < 0.00001), interleukin-13 (IL-13, MD = −7.30, 95% CI (−7.82, −6.79), P < 0.00001), and tumour necrosis factor-α (TNF-α, MD = −0.56, 95% CI (−0.64, −0.48), P < 0.00001), high-sensitivity C-reactive protein (hs-CRP, MD = −2.09, 95% CI (−2.47, −1.71), P < 0.00001), procalcitonin (PCT, MD = −2.04, 95% CI (−2.55, −1.53), P < 0.00001), arterial blood gas lactate (LaC, MD = −2.28, 95% CI (−2.45, −2.11), P < 0.00001), mechanical ventilation time (MD = −120.03, 95% CI…
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Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 1,061 participants or records.
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