Efficacy and safety of Xiaoer Feike Granules combined with azithromycin for Mycoplasma pneumoniae pneumonia: A systematic review and meta-analysis
Abstract
Background: The application of Xiaoer Feike Granules (XFG) in respiratory diseases has garnered significant attention. This study aims to quantitatively assess the efficacy and safety of XFG when combined with azithromycin for the treatment of Mycoplasma pneumoniae pneumonia (MPP). Methods: A comprehensive search of 8 public databases was conducted for relevant clinical trials published before July 1, 2024. The meta-analysis and trial sequential analysis were performed on the included studies. Results: Compared with azithromycin alone, the combination of XFG and azithromycin significantly improved the clinical effective rate (RR = 1.17, 95% CI = 1.13–1.22, P .05). Conclusion: Compared with azithromycin alone, XFG combined with azithromycin offers faster symptom resolution, reduced inflammation, and fewer adverse events. This combination may represent a safe and effective therapeutic strategy for MPP.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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