Multidimensional LDCT Imaging Endpoints for an Early-Phase Trial of Curcumin and Omega-3 Fatty Acids for Lung Cancer Chemoprevention: Results of a Randomized Pilot Trial
Abstract
Former smokers in lung cancer screening remain at elevated risk for lung cancer despite smoking cessation. We and others have shown that curcumin exhibits anti-inflammatory and antiproliferative effects but is limited by poor bioavailability. However, since curcumin is lipophilic, co-administration with omega-3 fatty acids (ω-3 ω-3 ω-3 FA) represents a mechanistically rational strategy to enhance delivery and target complementary pathways, including STAT3 and NF-κB signaling for lung cancer chemoprevention.
Methods:: We conducted a randomized, single-blind, placebo-controlled pilot study evaluating curcumin combined with ω-3 FA in high-risk former and current smokers with CT-detected pulmonary nodules. Participants received intervention agents or placebo for 6 months. Primary endpoints included radiologic changes in nodule size, number, and density. Secondary endpoints included safety, adherence, bioavailability, and exploratory biomarker analyses. Correlation analyses of imaging-derived metrics were performed to assess relationships among LDCT parameters.
Results:: Nineteen participants were enrolled (intervention, n=12; placebo, n=7). No statistically significant between-group differences were observed in primary imaging endpoints. The intervention was well tolerated, with predominantly grade 1 adverse events. Exploratory analyses demonstrated consistent positive correlations among LDCT-derived measures, with clustering of size-based metrics (mean diameter, volume, sum of…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 12 participants or records.
Read the paper
Related studies
- eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses
- Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer
- OptiType: precision HLA typing from next-generation sequencing data
- Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications
- Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases
- Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.