NeuroSparkSNT: An Eight-Operator Framework for Behavioral Phase Dynamics in C. elegans Neural Simulation
Abstract
Abstract The nematode C. elegans possesses one of the most thoroughly characterized nervous systems in biology, yet existing computational models of its locomotion occupy opposite architectural extremes: biophysi-cally detailed conductance-based simulations that faithfully reproduce single-neuron membrane dynamics but cannot account for the discrete, mutually exclusive transitions between behavioral states, and mean-field rate models that capture certain population-level statistics but sacrifice circuit specificity. Neither class was designed to reproduce the abrupt, all-or-none phase switching—forward crawling, reversal , omega-turn reorientation—that whole-brain calcium imaging has shown to be the defining dynamical signature of freely behaving C. elegans. We present NeuroSparkSNT, an eight-operator framework built directly on the Cook et al. (2019) connectome (114 of 300 neurons, spanning sensory, interneuron, and motor groups), in which a semi-Markov phase controller gates operator activity so that competing loco-motor drives are structurally, not merely numerically, exclusive. Two architectural variants are evaluated under identical biological parameters: a monolithic implementation in which all operators are evaluated at every simulation step, and a pool-dispatch implementation in which only the operators appropriate to the current phase are evaluated. Across twelve quantitative benchmarks calibrated against five independent experimental datasets, the pool-dispatch…
How strong is the evidence?
Evidence Hub reads this as a preprint, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses
- Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer
- OptiType: precision HLA typing from next-generation sequencing data
- Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications
- Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases
- Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.