Blockade of Vascular Potassium Channels During Human Endotoxemia
Abstract
Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.
Conditions: Endotoxemia.
Primary outcome: Hemodynamics; Markers of Inflammation; Cytokines; Markers of Renal Injury; Inducible NO synthase expression; NO-metabolites; Mediators of Vascular reactivity; Sensitivity to norepinephrine.
Enrollment: 36 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 36 participants or records.
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