A phase 2A, randomized, double-blind, placebo-controlled, parallel-group study of CE-224,535, an antagonist of the P2X7 receptor, in the treatment of the signs and symptoms of rheumatoid arthritis in subjects WHO are inadequately controlled on methotrexate
Abstract
CE-224,535 is known to block a chemical that acts as a gateway to some of your immune cells. Blocking this gateway prevents the cells from pushing out 2 chemicals called IL-1 and IL-18 that are known to cause some of the inflammation seen in rheumatoid arthritis. It is hoped that taking this drug will reduce the symptoms of rheumatoid arthritis
Conditions: Arthritis, Rheumatoid.
Primary outcome: Percentage of Participants With American College of Rheumatology 20% (ACR20) Response at Week 12.
Enrollment: 100 participants.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 100 participants or records.
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