Omega-3 Fatty Acids Supplementation Improves Pulmonary Function and Clinical Outcomes in Critically Ill Patients: a Meta-Analysis
Abstract
BACKGROUND: Although several studies have examined the relationship between omega-3 (ω-3) fatty acids and pulmonary function and clinical outcomes in critically ill patients, their findings remain mixed and inconclusive, and additional research is warranted.
OBJECTIVES: This study aimed to evaluate the effects of ω-3 fatty acids on pulmonary function and clinical outcomes in critically ill patients.
METHODS: We searched 5 databases (PubMed, Web of Science, Embase, EBSCO, and Cochrane Central Register of Controlled Trials) to identify randomized controlled trials involving critically ill adults who received ω-3 fatty acids. Both enteral and parenteral routes of administration were included. Effect estimates were pooled using fixed- or random-effects models, and heterogeneity among studies was assessed using the I2 statistic.
RESULTS: The analysis included 29 studies involving 2551 critically ill patients. The ω-3 fatty acids intervention significantly increased EPA and DHA levels. For inflammatory and immune markers, it increased CD4+ T lymphocytes, the CD4+/CD8+ ratio, and decreased C-reactive protein (CRP) levels. For pulmonary function, it increased PaO2, SaO2, and PaO2/FiO2, and decreased airway resistance, positive end expiratory pressure, and lactate levels. For clinical outcomes, it significantly shortened mechanical ventilation days [mean difference: -1.31; 95% confidence interval (CI): -2.54, -0.09; P = 0.04] and length of hospitalization (mean difference: -3.96; 95%…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 2,551 participants or records.
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