Omega-3 fatty acid supplementation for distal symmetrical peripheral neuropathy in adults with diabetes mellitus
Abstract
Rationale: Diffuse distal symmetrical polyneuropathy (DSPN) is a common complication in people living with diabetes mellitus. There is currently no effective treatment for DSPN. There is a biological rationale that omega-3 polyunsaturated fatty acids (PUFAs) may modify peripheral nerve function in DSPN. However, there is a lack of certainty about the potential benefits and harms of omega-3 PUFAs as a treatment for DSPN.
Objectives: To evaluate the benefits and harms of oral omega-3 PUFA supplements as a treatment for DSPN in adults with diabetes mellitus, compared to placebo or no treatment.
Search methods: We searched the Cochrane Neuromuscular Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, and two clinical trials registries, together with reference checking, to identify studies eligible for inclusion in the review. The latest search date was 12 June 2024.
Eligibility criteria: We included randomised controlled trials (RCTs) involving adults with type 1 diabetes, type 2 diabetes, or impaired glucose tolerance who had evidence of DSPN, that compared omega-3 PUFA supplements with placebo treatments or no treatment. We excluded studies with an intervention period of less than 180 days.
Outcomes: Our critical outcome was peripheral neuropathy impairment at six months after treatment. Other main outcomes were: symptoms of peripheral neuropathy, pain, quality of life, and adverse events, including any adverse events; adverse…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 87 participants or records.
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