Evaluating the Effects of Nanocurcumin Supplementation in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Abstract
Background: Nanocurcumin has been developed to overcome the poor bioavailability of conventional curcumin and has been proposed as a potential adjunctive therapy for type 2 diabetes mellitus (T2DM). However, evidence regarding its clinical efficacy remains inconsistent. This systematic review and meta-analysis aimed to evaluate the effects of nanocurcumin supplementation on glycemic control, lipid profile, inflammatory markers and oxidative stress in patients with T2DM.
Methods: A systematic search of PubMed, Scopus and the Cochrane Library was conducted from inception to October 2025 to identify randomized controlled trials (RCTs) assessing nanocurcumin supplementation in adults with T2DM. Eligible studies compared nanocurcumin with placebo or no intervention and reported outcomes related to glycemic indices, lipid parameters, inflammatory markers or oxidative stress. Pooled effect sizes were calculated using a random-effects model and expressed as standardized mean differences (SMDs) with 95% confidence intervals (CIs). Between-study heterogeneity was assessed using the I2 statistic.
Results: Seven RCTs involving 453 participants were included. Nanocurcumin supplementation showed no significant effects on fasting blood glucose (SMD: -0.44; 95% CI: -2.16 to 1.28), HbA1c (SMD: 0.19; 95% CI: -1.26 to 1.65), or lipid profile parameters, including total cholesterol, LDL-C, HDL-C and triglycerides (all p > 0.05). No statistically significant reduction in C-reactive protein was…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 453 participants or records.
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