Genetic evidence of the causal relationship between genetically predicted nutrients and psoriatic arthritis
Abstract
Background: Recently, the importance of nutrients in managing the immune system and inflammation has garnered increasing attention. Research indicates that different nutrients can either reduce or promote inflammation within the immune system. Considering that psoriatic arthritis is a chronic immune-mediated inflammatory disorder, this research sought to investigate potential causal relationships between genetically predicted levels of 25 nutrients and psoriatic arthritis, providing insights into disease pathogenesis and therapeutic strategies.
Patients and methods: This study performed a two-sample Mendelian randomization (MR) study along with subsequent meta-analysis. Exposures comprised 25 circulating nutrients, instrumented by genetic variants (IVs), low linkage disequilibrium, and absence of pleiotropy. Outcomes included PsA cases from FinnGen (discovery cohort: N cases/controls = 3537/262,844) and Soomro et al. [23] (validation cohort: N cases/controls = 5065/21,286). Primary causal estimates were derived via inverse-variance weighted (IVW) regression, supplemented by sensitivity analyses (MR-Egger, weighted median, MR-PRESSO) to evaluate heterogeneity, horizontal pleiotropy, and outliers. Fixed-effects meta-analysis integrated estimates across cohorts.
Results: Findings from the meta-analysis revealed a positive association between the risk of psoriatic arthritis and saturated fatty acids (OR = 1.1407, 95% CI 1.0095-1.2890, P = 0.0347) and linoleic acid (OR = 1.1536,…
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Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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