The effect of omega-3 supplementation on metabolic, inflammatory and oxidative stress biomarkers in pregnant women: a systematic review and meta-analysis
Abstract
Background: This meta-analysis evaluates the effects of omega-3 supplementation on metabolic, inflammatory, and oxidative stress in pregnancy women by synthesizing findings from randomized controlled trials (RCTs), as existing evidence remains inconclusive.
Methods: A systematic search was conducted using PubMed, Scopus, and Web of Science until July 2024. Random-effects models were applied to estimate each outcome's standardized mean difference (SMD) and 95% confidence intervals (CI).
Results: A total of 14 studies were included in the meta-analysis. The duration of omega-3 supplementation ranged from 6 to 29 weeks. Omega-3 supplementation did not have a significant effect on FBS (SMD = -0.74, 95% CI: -1.94, 0.45), and insulin (SMD = -0.76, 95% CI: -1.77, 0.24), TC (SMD = 0.11, 95% CI: -0.20, 0.42), and LDL-C (SMD = 0.32, 95% CI: -0.17, 0.81), IL-6 (SMD = 2.12, 95% CI: -0.56, 4.80), MDA (SMD = -1.67, 95% CI: -3.39, 0.05), and TAC (SMD = 2.59, 95% CI: -0.37, 5.54). However, triglyceride (SMD = -0.96, 95% CI: -1.77, -0.16) and CRP (SMD = -0.98, 95% CI: -1.86, -0.11) significantly decreased, and HDL-C cholesterol levels significantly increased (SMD = 0.72, 95% CI: 0.21, 1.22) following omega-3 supplementation.
Conclusion: This study suggests omega-3 supplementation may improve lipid profiles and reduce inflammatory biomarkers during pregnancy. However, the presence of heterogeneity across trials highlights the need for further well-conducted studies. Thus, findings should be…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses
- Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer
- OptiType: precision HLA typing from next-generation sequencing data
- Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications
- Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases
- Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.