What are the effects of omega-3 supplementation on anthropometric measurements and thyroid function in patients with Hashimoto's disease? A randomized controlled clinical trial
Abstract
BACKGROUND AND AIMS: This study aimed to examine the effects of omega-3 supplementation on anthropometric measures, thyroid hormone concentrations, and anti-TPO in Hashimoto's disease patients.
METHODS AND MATERIALS: This double-blind randomized clinical experiment randomly split 50 Hashimoto's disease patients into two groups, including treatment and placebo, which received 2000 mg/day omega-3 or placebo for 12 weeks. Before and after the trial, anthropometric measurements and plasma thyroid hormone concentrations T3, T4, thyroid-stimulating hormone (TSH), and anti-thyroid peroxidase antibody (TPO) were measured.
RESULTS: This research found that omega-3 supplementation in comparison with placebo significantly increased the serum level of group T4 (p = 0.032). Compared to the control group, the omega-3 group had a significant effect on the level of Anti-TPO (p = 0.040). The changes of TSH and T3 were not significantly different between intervention and control groups (p = 0.694 and p = 0.567).
CONCLUSION: This research found that administrating omega-3 in Hashimoto's disease enhanced thyroid function and less autoimmune activity.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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