Effects of a Commercial Fruit, Vegetable and Berry Juice Powder Concentrate on Metabolic Safety and Cardiovascular Health in Older Adults: 6-Month Results of a Randomized Controlled Trial
Abstract
Background/Objectives: Fruit, vegetable and berry (FVB) juice powder concentrates are increasingly used to support cardiovascular health. Since they are usually consumed over long periods, this study assessed the metabolic safety of a commercial FVB supplement and its impact on selected biomarkers of systemic oxidative stress and cardiovascular health. Methods: In this open-label, randomized controlled trial, generally healthy older adults were allocated to a control group (n = 16) or an FVB group (n = 18), ingesting six capsules/day. This work reports the pre-specified 6-month timepoint of a 1-year trial. The primary outcome, metabolic safety, was assessed by hepatic, renal, thyroid, lipid and glucose metabolism markers. Exploratory analysis assessed carbonyl proteins, malondialdehyde, and oxidized LDL as markers of systemic oxidative stress, together with homocysteine and blood pressure as markers of cardiovascular health, while plasma vitamin C served as a compliance marker. Results: The FVB concentrate was well tolerated, and no safety-relevant deteriorations were observed in the FVB group. Carbonyl proteins decreased significantly in the FVB group (interaction p = 0.030). Homocysteine remained stable in the FVB group but increased significantly in the control group (interaction p = 0.002). Furthermore, systolic blood pressure decreased significantly (interaction p = 0.036), with a comparable interaction of diastolic blood pressure (p = 0.011), and plasma vitamin C…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 18 participants or records.
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