Fish oil-derived eicosapentaenoic and docosahexaenoic acids enhances synthesis of pro-resolving oxylipins and improves growth performance and insulin sensitivity in feedlot cattle
Abstract
To investigate the impact of encapsulated fish oil (EFO) supplementation on growth performance, carcass characteristics, blood immunometabolic biomarkers, and adipose tissue inflammation in feedlot cattle, Angus × SimAngus crossbreed steers (n = 60; body weight [BW] = 320 ± 29 kg) were used in a randomized complete block design. Steers were blocked by BW and origin and randomly selected to receive 1 of 2 dietary treatments consisting of a finishing diet with 0.5% (DM basis) of either EFO or tallow (TLW) as supplemental lipid sources. To assess adipose tissue inflammation and plasma oxylipins, a subset of 6 steers per treatment were randomly selected for collection of adipose tissue (d -5, d 100, and postmortem) and blood samples (d -5, 56, 112, and 168). The luminescence intensity of the CD172a was used as a proxy of adipose tissue inflammation. For plasma metabolite analysis, blood samples were collected from all steers on d 56, 112, and 168. Mixed models (SAS PROC GLIMMIX and MIXED procedures) were used for statistical analyses. A treatment × d interaction was detected for BW (P = 0.03), where the EFO-supplemented steers were heavier throughout the experimental period and at study conclusion than the TLW-supplemented cohort. Steers supplemented with EFO exhibited a greater average daily gain compared to the TLW-supplemented group (P = 0.04). For the carcass characteristics, EFO-supplemented steers tended to have a heavier hot carcass weight and a greater Longissimus muscle…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 60 participants or records.
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