Effect of isotretinoin and omega-3 fatty acid combination on lipid metabolism in patients with acne vulgaris: a randomized controlled trial
Abstract
BACKGROUND: Acne vulgaris (AV) is a chronic inflammatory dermatological condition, and its underlying pathogenesis may be associated with dyslipidemia. Omega-3 fatty acids regulates lipid metabolism and reduce inflammation. However, their effects on blood lipids in AV have not yet been reported. This study’s objective is to investigate the serum lipid metabolomic differences between patients and healthy individuals and explore the effects of isotretinoin combined with omega-3 fatty acids on serum lipid metabolism in AV. METHODS: Between July 2020 and June 2021, 46 patients with acne vulgaris and 20 healthy controls were recruited from the Affiliated Hospital of Southwest Medical University. Untreated patients were randomly allocated to receive oral isotretinoin combined with or without omega-3 fatty acids for 6 months. Serum lipid metabolomics was performed using liquid chromatography-tandem mass spectrometry (LC-MS). Statistical analysis of the lipid metabolites was conducted by partial least squares-discriminant analysis (PLS-DA). Correlations between differential lipid metabolites and disease severity indicators were tested by Spearman’s correlation analysis. Metabolic pathways in the isotretinoin and omega-3 combination treatment group were analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. RESULTS: PLS-DA showed a clear separation of serum lipid metabolites between healthy controls and AV patients, with the combination treatment group showing a…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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