The association between liver fat content and plasma metabolite profiles in fasting and postprandial states: an integration of a cohort study and a randomized controlled trial
Abstract
Background: Postprandial metabolic impairments play a key role in the pathophysiology of cardiometabolic diseases. While liver fat content has been linked to distinct fasting metabolite profiles, its relationship with postprandial metabolite profiles remains unexplored. In this study, we aimed to (1) examine to what extent liver fat content is associated with the postprandial metabolomic profile beyond fasting metabolites; and (2) investigate whether diet-induced changes in liver fat content are associated with changes in plasma metabolites identified in objective 1.
Methods: In a subpopulation (n = 1986) of an existing cohort study and a 12-week dietary intervention study (n = 80), liver fat content was measured by proton magnetic resonance spectroscopy and categorized as low ( 5.5%). In the cohort study, plasma metabolomic profiles were quantified by NMR spectroscopy at fasting (T0) and 150 min after a mixed meal (T150). We examined associations between liver fat content and plasma metabolites at T0, T150 and postprandial response (ΔT150-T0) using multivariate linear regression. In the intervention study, plasma metabolomic profiles were quantified at fasting (T0) and at multiple postprandial time points (120, 240, and 360 min) following a mixed meal, both before and after the intervention. We further examined associations between liver fat content and plasma metabolites at T0, and postprandial response (incremental area under the curves [iAUCs]) and explored associations…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 1,986 participants or records.
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