Omega-3 and -6 fatty acid supplementation and sensory processing in toddlers with ASD symptomology born preterm: A randomized controlled trial
Abstract
Background: Despite advances in the health and long-term survival of infants born preterm, they continue to face developmental challenges including higher risk for autism spectrum disorder (ASD) and atypical sensory processing patterns. Aims: This secondary analysis aimed to describe sensory profiles and explore effects of combined dietary docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and gamma-linolenic acid (GLA) supplementation on parent-reported sensory processing in toddlers born preterm who were exhibiting ASD symptoms. Study design: 90-day randomized, double blinded, placebo-controlled trial. Subjects: 31 children aged 18–38 months who were born at ≤ 29 weeks’ gestation. Outcome measure: Mixed effects regression analyses followed intent to treat and explored effects on parent-reported sensory processing measured by the Infant/Toddler Sensory Profile (ITSP). Results: Baseline ITSP scores reflected atypical sensory processing, with the majority of atypical scores falling below the mean. Sensory processing sections: auditory (above = 0%, below = 65%), vestibular (above = 13%, below = 48%), tactile (above = 3%, below = 35%), oral sensory (above = 10%; below = 26%), visual (above = 10%, below = 16%); sensory processing quadrants: low registration (above = 3%; below = 71%), sensation avoiding (above = 3%; below = 39%), sensory sensitivity (above = 3%; below = 35%), and sensation seeking (above = 10%; below = 19%). Twenty-eight of 31 children randomized had…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 31 participants or records.
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